Predictive role of the modified Glasgow prognostic score for in-hospital mortality in stable acute pulmonary embolism

Abstract

Background and importanceThe modified Glasgow prognostic score (mGPS) has been reported to have a prognostic value in various patient populations. However, the prognostic significance of mGPS has not been studied inacute pulmonary embolism (APE). ObjectiveThis study aimed to investigate the predictive value of mGPS on in-hospital mortality in patients with hemodynamically stableAPE. MethodsWe retrospectively included 258 hemodynamically stableAPE patients. Clinical, echocardiographic, and laboratory data recorded on admission. The mGPS scored as 0, 1, or 2 based on the C-reactive protein (CRP) and albumin levels. ResultsA total of 258hemodynamically stableAPE patients were included, and 28 (10.9%) died during the hospital stay. Compared with survivors, non-survivors were older, had higher N-terminal pro-B-type natriuretic peptide, CRP, creatinine, high-sensitive cardiac troponin T (hs-cTnT), and mGPS levels, and had higher pulmonary embolism severity index (PESI) at study entry. In the multivariate logistic regression analysis, NT-proBNP>2350pg/mL (OR: 2.180, 95% CI 1.102–5.213, p<0.001), hs-cTnT>21pg/mL (OR: 1.426, 95% CI 1.151–3.751, p=0.001), CRP>3.1mg/dL (OR: 1.567, 95% CI 1.072–4.429, p=0.001), PESI>139 (OR: 2.745, 95% CI 1.869–6.369, p=0.001), systolic blood pressure<100mmHg (OR: 3.465, 95% CI 1.867–8.934, p<0.001), mGPS=1 (OR: 2.120, 95% CI 1.089–3.754, p=0.011), and mGPS=2 (OR: 3.350, 95% CI 1.457–5.367, p<0.001) were independently associated with in-hospital mortality. ConclusionThis study demonstrates the mGPS, which is a new and easily measurable marker, is a useful predictor in-hospital mortality in hemodynamically stableAPE.