Abstract
Objective: We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes.Study design: This was a multicenter, retrospective cohort study conducted in China. We selected 178 709 singletons weighing ≥2500 g with gestational age 37–44 weeks. We categorized macrosomia with two gradations (4000–4499 g and ≥4500 g) and compared them with a normosomic reference group of infants with birthweight 2500–3999 g.Results: The risks of obstetric and neonatal complications increased when infants had a birthweight of ≥4000 g. The rates of infant mortality, Apgar score ≤3 at 5 min, respiratory and neurological disorders rose significantly among neonates weighing ≥4500 g.Conclusion: A definition of macrosomia as birthweight ≥4000 g could be beneficial as an indicator of obstetric and newborn complications, and birthweight ≥4500 g might be predictive of severe infant morbidity and mortality risk.
Published Version
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