Predictive factors of the outcome of cerebral venous sinus thrombsis a retrospective ,case series study of 26 patients

Abstract

Objective To investigate the predictive factors of long-term outcome of cerebral venous sinus thrombosis （CVST）. Methods The clinical data of 26 patients with CVST were analyzed retrospectively. The clinical outcome was assessed with the modified Rankin Scale （mRS） at 6 months after symptom onset. Univariate and multivariate analysis were used to determine the independent predictors of the long-term poor outcome. Results The mRS scores for 26 patients with CVST： 0 to 1 in 19 cases, 2 in 2 cases, 3 to 5 in 3 cases, and 6 in 2 cases. 19.2% of patients had poor outcome （mRS score, ≥3）, and the mortality rate was 7.7%. The survivors did not have any recurrence within 6 months. Univariate analysis showed that disturbance of consciousness, papiUoedema, cerebral edema, and cerebral deep venous thrombosis were the possible risk factors for poor outcome, while headache was the main clinical manifestation, which was negatively correlated with the poor prognosis. Multivariate regression analysis showed that disturbance of consciousness was an independent predictor of poor outcome in patients with CVST （odds ratio, 48.0, 95% confidence interval 2. 311 to 997. 176, P =0. 012）. Conclusions The long-term outcome of the patients was better, disturbance of consciousness was an independent predictor of poor outcome at 6 months after the onset. Key words: Sinus thrombosis, intraeranial; Cerebral veins; Venous thrombosis; Intracranial thrombosis; Prognosis; Risk factors