Abstract
Objective: To determine the predictive factors that influence the outcome of Double “J” (DJ) stent placement in stage IIIB cervical cancer patients with hydronephrosis complications. Methods: An analytical observational study with a historical cohort was performed. Patients included in this study was patient with stage IIIB cervical cancer with hydronephrosis complication at Sanglah hospital. We analyzed the influence of time range since diagnosis until DJ stent placement, degree of hydronephrosis, and glomerular filtration rate on the outcomes of DJ stent placement namely: Lower urinary tract symptoms (LUTS), quality of life (QoL), and glomerular filtration rate changes (GFR). Data were tabulated and statistically analyzed using SPSS 25. Results: Of the 44 samples, the mean age of the patients was 51,93 (±7.672) years. Late DJ stent placement increase the risk of severe LUTS (RR: 3.103; 95%CI: 1.319-7.301; p<0.001) compared to patients with early DJ stent placement. We also found that a low glomerular filtration rate (bad renal function) is significantly associated with worse quality of life (RR: 1.917; 95%CI: 1.296-2.835; p<0.001). Conclusion: Delayed DJ stent placement is associated with severe LUTS symptoms, and poor renal function resulted in a poor quality of life.
Highlights
Late Double “J” (DJ) stent placement increase the risk of severe Lower urinary tract symptoms (LUTS) (RR: 3.103; 95%CI: 1.319-7.301; p
We found that a low glomerular filtration rate is significantly associated with worse quality of life (RR: 1.917; 95%CI: 1.296-2.835; p
Delayed DJ stent placement is associated with severe LUTS symptoms, and poor renal function resulted in a poor quality of life
Summary
Patients' quality of life and might give rise to Annually, estimated around 15.000 new many other symptoms. Double “J” stent cases of cervical cancer in Indonesia. Sanglah Central Hospital in Bali The placement of the DJ stent hoped to recorded 69 cases of cervical cancer treated manage the obstruction of the ureter, prevent from 2016 to 2017 with more than 90% of the deterioration of renal function, improve them being in the late stage. quality of life, and prevent urinary tract. Study from Shehab, et cervical cancer patients is hydronephrosis al shows the improvement of glomerular complication This complication resulted from filtration rates (GFR) that used as the direct invasion of the tumor, pressure from parameter of renal function.. The factors observed in this study include the of hemodialysis, and patient with a history of time range from the diagnosis of cervical using medication that could alter renal cancer to the time of DJ stent placements, the function examination (e.g., long term initial glomerular filtration rate, and the degree analgetic). Sample (LUTS), patient quality of life (QoL), and characteristics are presented as continuous and changes in glomerular filtration rates
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