Abstract
Background. The prevalence of impaired carbohydrate metabolism among women of reproductive age is increasing worldwide. Despite tremendous progress in the treatment and management of blood glucose levels, pregnancy in women with pregestational diabetes still carries risks for the fetus.
 This study aims to develop a calculator for predicting perinatal complications in women with pregestational diabetes mellitus by mathematical modeling.
 Materials and Methods. This observational analytical study with a case-control design was conducted at the Altai Regional Clinical Perinatal Center DAR (Barnaul). The study included 147 women, with the main group comprising 95 pregnant women, including 47 with type 1 diabetes mellitus (group 1A) and 48 with type 2 diabetes mellitus (group 1B). No carbohydrate metabolism disorders were detected in 52 patients of the control group. All patients in the main group received insulin therapy. Medical documentation was analyzed, and statistical processing of the data was performed using mathematical modeling methods with appropriate software.
 Results. In order to predict the combined indicator of perinatal complications, logistic regression analysis was used to calculate coefficients (b) for each of the indicators that have the most significant influence on the formation of complications.
 The calculated values of regression coefficients can be utilized to predict the risk of perinatal complications in women with type 1 diabetes mellitus. For more practical use, a calculator for assessing the risk of perinatal complications in type 1 and type 2 diabetes mellitus was created using a computer program.
 Diagnostic evaluation of the prognostic scale (calculator) for assessing perinatal complications risk assessment in type 2 diabetes mellitus demonstrated a sensitivity of 97.6%, specificity of 87.5%, and a prognostic value of positive risk assessment of 97.5%. Therefore, the calculator enables the prediction of the risk of perinatal complications in 97.5% of cases. At the same time, the prognostic scale of perinatal complications risk and the Perinatal Complications Risk Calculator for type 1 diabetes mellitus created on its basis showed 100% sensitivity and specificity.
 Conclusion. The frequency of perinatal complications remains high, so the creation of a sufficiently effective prognostic model will make it possible to predict perinatal complications and influence the tactics of management of pregnant women and their newborns.
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More From: V.F.Snegirev Archives of Obstetrics and Gynecology
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