Prediction of The Risk for Hypertension Among Carrier of C825T Genetic Polymorphism of G Protein Beta 3 Gene (GNB3)

Abstract

BackgroundGNB3 825T is associated with the occurrence of the splice variant Gß3s, which, despite a deletion of 41 amino acids, is functionally active in reconstituted systems. This may cause enhanced vascular reactivity and increased proliferation of smooth muscle cells and cardiac myocytes, ultimately resulting in vascular and myocardial hypertrophy.AimTo predict the risk for hypertension in individuals with C825T genetic polymorphism of G protein β3 gene.Material and MethodThe study consisted of 192 normotensive individuals and 120 hypertensive patients. Individuals were genotyped for C825T genetic polymorphism of G protein β3 gene by using polymerase chain reaction‐ restriction fragment length polymorphism. Statistical analysis was done by SPSS program.ResultsFrequency of C and T alleles were 47.5% and 52.5% in hypertensive group compared to 62% and 38% in control group. The carriers of T allele exhibited a significant greater risk for hypertension compared to carriers of C allele (OR= 1.8, 95%CI= 1.3–2.6).ConclusionT allele is a risk factor for hypertension.Source of Fund: DMCG