Abstract
Fifteen substituted amides (hydrazides) of N-acyl-5-bromo(3,5-dibromo)anthranilic acids were synthesized. Potentiometric titration was used to measure ionization constants for each compound, and quantum chemical parameters were calculated. Four correlational equations were obtained linking ionization constants with quantum chemical parameters. These equations were used to calculate predicted values for the ionization constants of four new compounds of this series. The theoretically calculated values were confirmed experimentally. The correlational equations identified here can thus be used to predict ionization constants in this series of substituted amides (hydrazides) of N-acyl-5-bromo(3,5-dibromo)anthranilic acids and in further studies of structure-activity relationships.
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