Prediction of Genetic Alterations in Oncogenic Signaling Pathways in Squamous Cell Carcinoma of the Head and Neck: Radiogenomic Analysis Based on Computed Tomography Images.

Abstract

ObjectiveThis study investigated the role of radiomics in evaluating the alterations of oncogenic signaling pathways in head and neck cancer.MethodsRadiomics features were extracted from 106 enhanced computed tomography images with head and neck squamous cell carcinoma. Support vector machine–recursive feature elimination was used for feature selection. Support vector machine algorithm was used to develop radiomics scores to predict genetic alterations in oncogenic signaling pathways. The performance was evaluated by the area under the curve (AUC) of the receiver operating characteristic curve.ResultsThe alterations of the Cell Cycle, HIPPO, NOTCH, PI3K, RTK RAS, and TP53 signaling pathways were predicted by radiomics scores. The AUC values of the training cohort were 0.94, 0.91, 0.94, 0.93, 0.87, and 0.93, respectively. The AUC values of the validation cohort were all greater than 0.7.ConclusionsRadiogenomics is a new method for noninvasive acquisition of tumor molecular information at the genetic level.