Prediction of Acute Kidney Injury After Coronary Artery Bypass Graft From Preoperative Serum Uric Acid

Abstract

ObjectiveAcute kidney injury (AKI) frequently occurs during coronary artery bypass graft (CABG) procedures and poses challenges in terms of prognostication. This study aimed to examine the association of a heightened level of uric acid (UA) in the bloodstream and a heightened likelihood of AKI following CABG surgery. DesignThis is a retrospective cohort study. The research utilised a multivariate logistic regression model. SettingThe study was performed as a single institution. ParticipantsAll patients underwent CABG. InterventionNo interventions were imposed on participants. Measurements and Main ResultsA total of 761 individuals who underwent CABG were included in our study. The participants were categorised into four groups based on their UA levels: the Q1 group (UA <292.5 μmol/L), the Q2 group (292.5≤ UA <353 μmol/L), the Q3 group (353≤ UA <423 μmol/L), and the Q4 group (UA ≥423 μmol/L). A total of 167 patients, accounting for 21.9% of the sample, experienced postoperative AKI. The study found the risk of AKI was significantly higher in the Q4 group compared to the Q1 group, with percentages of 40.4% and 8.9% respectively (P< 0.001). Following the adjustment for confounding variables, it was determined that there exists an independent association between serum UA concentration and an elevated risk of AKI subsequent to CABG (odds ratio [OR], 95% confidence interval [CI] 6.41, 3.49-12.32, P< 0.001, P for trend< 0.001). ConclusionA relationship can be observed between preoperative blood UA levels and the occurrence of AKI following CABG surgery.