Predicting membrane curvature sensing and remodeling by protein domains and assemblies using continuum models

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Protein self-assembly is essential for many biological processes on membranes, including virion formation and clathrin-mediated endocytosis. During the self-assembly process, proteins interact not only with each other, but also interact with the lipid membrane, which is essential for driving membrane remodeling. Membrane bending is generated by multiple mechanisms, including helix insertion and scaffolding by protein structures, which we study here. We developed a continuum membrane model to study curvature sensing and induction by individual domains and assembled domains of proteins.