Abstract
Aptamers, in sensing technology, are famous for their role as receptors in versatile applications due to their high specificity and selectivity to a wide range of targets including proteins, small molecules, oligonucleotides, metal ions, viruses, and cells. The outburst of field-effect transistors provides a label-free detection and ultra-sensitive technique with significantly improved results in terms of detection of substances. However, their combination in this field is challenged by several factors. Recent advances in the discovery of aptamers and studies of Field-Effect Transistor (FET) aptasensors overcome these limitations and potentially expand the dominance of aptamers in the biosensor market.
Highlights
One and a half century since the discovery of nucleic acid by Meister in 1869 [1], the properties and functions of aptamers have attracted significant research attention
Aptamers are among the most crucial nucleic acid species with versatile applications in separation, analytics, and molecular imaging, in diagnosis and therapeutics. This perspective provides a prediction about the future development of aptamers in Field-Effect Transitor (FET)-based biosensors, a narrow field of sensing technology
Since FETs have been employed as transducers for biosensors, antibodies are the most widely applied recognition factor because of their simplicity, low-cost synthesis and ability to be immobilized on various surfaces
Summary
One and a half century since the discovery of nucleic acid by Meister in 1869 [1], the properties and functions of aptamers have attracted significant research attention. Aptamers are among the most crucial nucleic acid species with versatile applications in separation, analytics, and molecular imaging, in diagnosis and therapeutics. This perspective provides a prediction about the future development of aptamers in Field-Effect Transitor (FET)-based biosensors, a narrow field of sensing technology. We follow with a summary about the key characteristics of FET and the major role of aptamers in sensing techniques employing this transducer. The content of these three sections foreshadows our final view on the matter as expressed in the final part
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