Predicting brain states associated with object categories from fMRI data.

Abstract

Recently, the multivariate analysis methods have been widely used for predicting the human cognitive states from fMRI data. Here, we explore the possibility of predicting the human cognitive states using a pattern of brain activities associated with thinking about concrete objects. The fMRI signals in conjunction with pattern recognition methods were used for the analysis of cognitive functions associated with viewing of 60 object pictures named by the words in 12 categories. The important step in Multi Voxel Pattern Analysis (MVPA) is feature extraction and feature selection parts. In this study, the new feature selection method (accuracy method) was developed for multi-class fMRI dataset to select the informative voxels corresponding to the objects category from the whole brain voxels. Here the result of three multivariate classifiers namely, Naïve Bayes, K-nearest neighbor and support vector machine, were compared for predicting the category of presented objects from activation BOLD patterns in human whole brain. We investigated whether the multivariate classifiers are capable to find the associated regions of the brain with the visual presentation of categories of various objects. Overall Naïve Bayes classifier perfumed best and it was the best method for extracting features from the whole brain data. In addition, the results of this study indicate that thinking about different semantic categories of objects have an effect on different spatial patterns of neural activation, and so it is possible to identify the category of the objects based on the patterns of neural activation recorded during representation of object line drawing from participants with high accuracy. Finally we demonstrated that the selected brain regions that were informative for object categorization were similar across subjects and this distribution of selected voxels on the cortex may neutrally represent the various object's category properties.