Predicted prevalence of oral human papillomavirus (HPV) by periodontitis status and HPV vaccination status

Abstract

The purpose of the present study was to examine differences in oral human papillomavirus (HPV) prevalence among adults based on HPV vaccination status and periodontitis status. Data from 2011 to 2012 and 2013 to2014 National Health and Nutrition Examination Surveys (n = 822) were retrieved in order to predict the prevalence of oral HPV in 24 separate demographic groups (age by sex by race) based on the following characteristics: HPV vaccination status and periodontitis status. A multiple logistic regression model, controlling for gender, age, race, smoking behavior, alcohol consumption, and sexual partners, was calculated in order to generate prevalence estimates. Median predicted oral HPV prevalence rates per 1,000 in 2011-2012 were highest among nonvaccinated individuals with periodontitis [median ( ) = 31.62, interquartile range (IQR) = 102.97], followed by nonvaccinated individuals without periodontitis ( = 24.63, IQR = 81.84), vaccinated individuals with periodontitis ( = 18.40, IQR = 62.27), and vaccinated individuals without periodontitis ( = 14.29, IQR = 48.96). Median predicted oral HPV prevalence rates per 1,000 in 2013-2014 were highest among nonvaccinated individuals with periodontitis ( = 9.50, IQR = 33.02), followed by nonvaccinated individuals without periodontitis ( = 7.37, IQR = 25.76), vaccinated individuals with periodontitis ( = 5.48, IQR = 19.27), and vaccinated individuals without periodontitis ( = 4.25, IQR = 14.98). Interventions that integrate primary care and dental care are needed, given increased risk for oral HPV among unvaccinated individuals with periodontitis.