Abstract
Purpose: Cartilage lacks an innate repair capability after traumatic injury. As such, focal cartilage defects have been implicated as a potential initiator of early osteoarthritic disease, and early treatment of chondral defects may prevent or delay the development of osteoarthritis and improve patient quality of life. Cell sheet technology using temperature responsive cultureware allows production of confluently cultured cells as sheets. Harvested sheets are readily patched on tissue lesions and adhere without suture, fibrin glue or other adhesion techniques.
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