Precious platelets: The utility of cold-stored and cryopreserved platelets

Abstract

The current storage temperature of platelets prepared by both pooled buffy coats and by apheresis is 22°C + 2°C (room temperature [RT]). The adverse microbiological and metabolic implications associated with RT storage have restricted the shelf life of platelets from 5 to 7 days. The proposed alternative is cold-stored (4°C) platelets that could be stored for 21 days and cryopreserved platelets with dimethyl sulfoxide for up to 2 years at −80°C. An increase in shelf life could be of great utility in rural and military settings. Based on the proven quality and properties of cold-stored platelets, the US Food and Drug Authority has approved its use for up to 3 days in patients having active bleeding.