Prebiotics, probiotics and fecal microbiota transplantation in autism: A systematic review

Abstract

In recent years, there has been an increase in studies of the implications of the gut microbiota (GM) in children with ASD. There is a hypothesis which propose a relationship between the emotional state and the abundance of intestinal microbes through the so-called microbiota-intestine-brain axis. In this sense, dysbiotic GM could be a contributing factor to the appearance of ASD. This systematic review article analyses the results of the intervention using prebiotics (Ascidians, Aspergillus niger, vitamin A, myeloperoxidase, etc.), probiotics (mainly: Lactobacillus, Bifidobacterium, etc.) and Transplantation of Fecal Microbiota in ASD children. In conclusion, the results of the initial studies suggest changes in ASD symptoms, gastro-intestinal symptoms and GM composition after the interventions. However, the results should be taken with caution because there are very few studies that analyse the efficacy of long-term treatments and the different combinations of them.