Abstract
In this study, an extracellular acidic polysaccharide (EAPS) from marine Rhodotorula sp. RY1801 was extracted, and its biological properties were investigated. EAPS is mainly composed of monosaccharides, including mannose, rhamnose, glucose, galactose, and fucose, had an average molecular weight of 5.902 × 107 Da. The results indicated that EAPS can promote the growth of Lactobacillus acidophilus and L. acidophilus plantarum. EAPS is capable of scavenging both superoxide anion and hydroxyl radicals in vitro. The highest scavenging rate of superoxide anion and hydroxyl radicals is 29 and 84%, respectively. Using in vivo model, we found that the EAPS can expand the lifespan and increase the disease resistance of Caenorhabditis elegans against Klebsiella pneumoniae infection via the DAF-2/DAF-16 pathway. These results suggested that EAPS from marine Rhodotorula sp. RY1801 could promote the growth of beneficial bacteria and can be used as an antioxidant and immunomodulator, which had considerable potential in the food and health industry.
Highlights
A polysaccharide is formed by linking 10 or more monosaccharides to each other through glycosidic bonds
The extracellular acidic polysaccharide (EAPS) exhibited great potential to be developed into a valuable additive for the food and pharmaceutical industries
The extracellular polysaccharide was obtained from marine Rhodotorula RY1801 by alcohol precipitation, dialysis, and lyophilization
Summary
A polysaccharide is formed by linking 10 or more monosaccharides to each other through glycosidic bonds. Since the 1950s, the study of polysaccharides has aroused the interest of researchers and has gradually become a hotspot [1]. After an in-depth study of various polysaccharides, researchers found that natural polysaccharides, like Flammulina velutipes polysaccharide, Dendrobium huoshanense polysaccharide, Sargassum horneri polysaccharide, Moringa oleifera polysaccharide, Ganoderma lucidum polysaccharide, and Astragalus polysaccharide, have good biological activities, such as antitumor, immunomodulation, antiviral, antibacterial, antioxidant, hypoglycemic, hypolipidemic, and some other functions [2]. In addition to bacterial capsule polysaccharides, many other microbial polysaccharides are of interest to researchers, some of which have been maturely developed for use in the food, agriculture, and healthcare industries. In the food industry, microbial polysaccharides are often used as stabilizers, thickeners, gelling agents, and processing excipients to improve the quality of food [6, 7], alginate and xanthan gum can be obtained from
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