Abstract
Background Multi-organ disease with cardiac involvement carries a very poor prognosis in Systemic AL Amyloidosis. The risk of nephrogenic systemic fibrosis is a significant obstacle in assessing cardiac status using CMR in patients with systemic AL amyloidosis who have advanced renal failure. Measurement of myocardial T1 values has been limited until now, due to long breathhold times. We have developed a robust and clinically applicable technique for diagnosing cardiac amyloidosis by measuring absolute myocardial T1 values using the single breath hold, Shortened Modified Look-Locker Inversion Recovery (ShMOLLI) sequence without gadolinium administration.
Highlights
Multi-organ disease with cardiac involvement carries a very poor prognosis in Systemic AL Amyloidosis
We have developed a robust and clinically applicable technique for diagnosing cardiac amyloidosis by measuring absolute myocardial T1 values using the single breath hold, Shortened Modified Look-Locker Inversion Recovery (ShMOLLI) sequence without gadolinium administration
Thirty-five patients (23 males, 12 females, mean age 60 years) with systemic AL amyloidosis underwent conventional CMR scanning with cine imaging and late gadolinium imaging as well as ShMOLLI pre-contrast T1mapping between both centres; all patients had an eGFR of >30ml/min
Summary
Multi-organ disease with cardiac involvement carries a very poor prognosis in Systemic AL Amyloidosis. Pre-contrast ShMOLLI T1 mapping in cardiac AL amyloidosis Background Multi-organ disease with cardiac involvement carries a very poor prognosis in Systemic AL Amyloidosis.
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