Abstract
Abstract Cyclic bis(3′–5′)diadenylic acid (c-di-AMP) (Chart 1), recently identified as a second messenger monitoring DNA integrity during sporulation in the soil bacterium Bacillus subtilis, was synthesized on an 80 µmol scale by a combination of the phosphoramidite and phosphotriester methods using a commercially available adenosine phosphoramidite as starting material. An artificial analog 2′-bis(tert-butyldimethylsilyl)-c-di-AMP was also obtained by our procedure.
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