Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

Hiroaki Mamiya,Takashi Naka,Yoshihiko Takeda,Balachandran Jeyadevan,Guoping Chen,Naoki Kawazoe

doi:10.1155/2017/1047697

Abstract

Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude Hac for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency f of 25 kHz. The limit corresponds to the value Hacf of 2.5 × 106 Oe·s−1 and is significantly lower than the conventionally accepted criteria of 6 × 107 Oe·s−1. The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.

Highlights

“if a steel pan made for induction heating (IH) cooking appliances is diced up into ultra-small pieces (magnetic nanoparticles) and selectively delivered to metastasized tiny cancers, and if the entire human body is placed on a cooking top, all cancers including unidentifiable ones will be burned without long-term side effects, resulting in a complete cure.” The realization of this scenario corresponds to an ideal therapy, and complete body magnetic fluid hyperthermia cancer therapy is intensively investigated by previous studies as an option in new cancer treatments to replace surgery, radiation therapy, and chemotherapy [1,2,3,4,5,6,7,8]
“if a steel pan made for induction heating (IH) cooking appliances is diced up into ultra-small pieces and selectively delivered to metastasized tiny cancers, and if the entire human body is placed on a cooking top, all cancers including unidentifiable ones will be burned without long-term side effects, resulting in a complete cure.”
The realization of this scenario corresponds to an ideal therapy, and complete body magnetic fluid hyperthermia cancer therapy is intensively investigated by previous studies as an option in new cancer treatments to replace surgery, radiation therapy, and chemotherapy [1,2,3,4,5,6,7,8]

Summary

Introduction

“if a steel pan made for induction heating (IH) cooking appliances is diced up into ultra-small pieces (magnetic nanoparticles) and selectively delivered to metastasized tiny cancers, and if the entire human body is placed on a cooking top, all cancers including unidentifiable ones will be burned without long-term side effects, resulting in a complete cure.” The realization of this scenario corresponds to an ideal therapy, and complete body magnetic fluid hyperthermia cancer therapy is intensively investigated by previous studies as an option in new cancer treatments to replace surgery, radiation therapy, and chemotherapy [1,2,3,4,5,6,7,8]. The new limit is considered to clarify whether or not the heating power of the present magnetic nanoparticles is sufficient to annihilate cancer cells including unidentifiable metastatic tiny cancerous areas scattered throughout the body via conventional magnetic fluid hyperthermia therapy.

Results

Conclusion