Abstract
Magnetic fluid hyperthermia (MFH) therapy uses the magnetic component of electromagnetic fields in the radiofrequency spectrum to couple energy to magnetic nanoparticles inside tumors. In MFH therapy, magnetic fluid is injected into tumors and an alternating current (AC) magnetic flux is applied to heat the magnetic fluid- filled tumor. If the temperature can be maintained at the therapeutic threshold of 42°C for 30 minutes or more, the tumor cells can be destroyed. Analyzing the distribution of the magnetic fluid injected into tumors prior to the heating step in MFH therapy is an essential criterion for homogenous heating of tumors, since a decision can then be taken on the strength and localization of the applied external AC magnetic flux density needed to destroy the tumor without affecting healthy cells. This paper proposes a methodology for analyzing the distribution of magnetic fluid in a tumor by a specifically designed giant magnetoresistance (GMR) probe prior to MFH heat treatment. Experimental results analyzing the distribution of magnetic fluid suggest that different magnetic fluid weight densities could be estimated inside a single tumor by the GMR probe.
Highlights
Hyperthermia therapy is a cancer treatment technique that uses heat to destroy tumors
For the case when Dw inside C1 (Dwi) is higher than Dwo, there is a significant decrease in the B values when moving from cavity 1 (C1) to cavity 2 (C2), and this decrease, as for the case when Dwi is lower than Dwo, is proportional to the Dw values (Figure 6 (A)-(ii))
This paper investigated the feasibility of analyzing the distribution of magnetic fluid, as used in Magnetic fluid hyperthermia (MFH) therapy, utilizing a giant magnetoresistance (GMR) probe
Summary
Hyperthermia therapy is a cancer treatment technique that uses heat to destroy tumors. Magnetic fluid hyperthermia (MFH) seeks to address these two issues by injecting magnetic nanoparticles into the tumor region, thereby selectively targeting tumor tissue and depositing heat in a localized manner [7,8,9,10]. The energy absorbed from the AC magnetic flux is transformed to heat due to Neel relaxation and Brownian motion of the magnetic nanoparticles [7]. Such localized treatment, which results in very high spatial selectivity in the target region, cannot be achieved with radiationbased therapies because unwanted heating due to the electrical conductivity of healthy tissues cannot be avoided during radiation. Unlike radiation-based therapies, MFH can target deep-seated tumors since the penetration depth does not depend on the frequency
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