Abstract
The enantioselective methylation reaction of phenyloxazoline tert-butyl ester 5 using ( R)- 4b as a catalyst under mild phase-transfer conditions provides optically active α-methylserine derivatives in moderate yields with high enantioselectivity. Other α-alkylated serine derivatives are also achievable in high yields with high enantioselectivity by using catalytic amount of ( R)- 4b.
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