PPR (koyun keçi vebası) ve mavidil aşısının merinos ırkı koyunlarda eş zamanlı uygulanabilirliğinin araştırılması

Abstract

Abstract: Peste des Petits Ruminants (PPR) and Bluetongue (BT), which are among the contagious animal diseases, cause serious economic losses and are included in the notifiable diseases by the World Organization for Animal Health (WOAH). PPR and BT vaccines are widely used in countries where outbreaks occur. In this study, we aimed to examine the neutralizing antibody response of simultaneously administered PPR and BT serotype 4 vaccines in sheep. For this purpose, a study was performed under field conditions in a state-owned breeding farm. All the experimental animals were confirmed seronegative by serum neutralization test (SNT) for antibodies to the PPR virus (PPRV) and BT virus serotype 4 (BTV4). Subsequently, the experimental animals were divided into four groups. Group 1 (Group 1/PPR; lamb n=10, sheep n=10) and group 2 (Group 2/BTV4; lamb n=10, sheep n=10) were vaccinated separately with the PPR and BTV4 vaccines. Group 3 was vaccinated simultaneously with PPR and BTV4 (Group 3/PPR-BTV4; lamb n=10, sheep n=10). Group 4 was unvaccinated and served as the control. In each of the experimental groups, the vaccinations were carried out only once. Post-vaccination blood samples were collected at intervals of 1, 3, and 6 months. A total of 280 post-vaccination blood serum samples were evaluated with SNT for PPRV and BTV4 neutralizing antibodies. When the neutralizing antibody levels between the groups were compared, group 3 did not show any statistically significant difference (p>0.05) from group 1 and group 2. Based on the antibody response of simultaneous vaccination, it is shown that the simultaneous vaccination could be administered on the field, and could be labor and cost-effective.