Abstract
A simple, efficient and green method for the synthesis of 4,6-diaryl- 2,3a,4,5-tetrahydro-3H-indazol-3-ones has been described using 3,5-diaryl-6-car- bethoxy cyclohexenones in the presence of silica gel-supported polyphosphoric acid, an effective and reusable catalyst, under solvent-free conditions. The starting 3,5-diaryl-6-carbethoxy cyclohexenones have been synthesized by the Michael addition of chalcones and ethylacetoacetate followed by internal Claisen conden- sation using K2CO3 in solvent-free conditions. The present methodology offers several advantages, such as short reaction time, high yield, and the absence of volatile and hazardous organic solvents. Structural assignments are based on 1 H, 13 C NMR, FTIR, and C, H, N analysis.
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