Abstract
Silica gel–supported polyphosphoric acid (PPA-SiO2) was found to be an efficient catalyst for the one-pot condensation reaction of aryl aldehydes, ethyl acetoacetate, and ammonium acetate to afford the corresponding 1,4-dihydropyridines in excellent yields. The main advantages of the present approach are short reaction times, clean reaction profiles, and simple experimental and work-up procedures.
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