Abstract
BackgroundThe +294T/C polymorphism in the peroxisome proliferator-activated receptor delta (PPARD) gene is associated with hyperlipidemia in several younger populations, but results are still inconsistence across ethnic groups and its possible impact on the lipid profiles of long-lived individuals remains unexploited. Here, we aimed to evaluate the possible correlation between PPARD +294T/C and serum lipid levels in a long-lived population in Bama, a region known for longevity situated in Guangxi, China.MethodsGenotyping of PPARD +294T/C polymorphism was conducted in 505 long-lived inhabitants (aged 90 and above, long-lived group, LG) and 468 healthy controls (aged 60–75, non-long-lived group, non-LG) recruited from Bama area.ResultsNo difference in allelic and genotypic frequencies was found between the two groups (P > 0.05). However, C-allele and C-genotype (TC and CC) were significantly more frequent in the females of non-LG than were LG after sex stratification. CC carriers exhibited higher LDL-C level in LG (P < 0.05) but lower TC, TG and LDL-C in non-LG (P < 0.05 for each) than TT carriers; C allele carriers (TC/CC) in LG exhibited higher TC, TG, and LDL-C levels as compared with the same genotype and the same lipid parameter in non-LG (P < 0.05 for each). LDL-C in LG was correlated with genotypes while TC, TG, and LDL-C in non-LG were correlated with genotypes (P < 0.05-0.001).ConclusionOur results suggest that there were different impact patterns of PPARD +294T/C polymorphism on lipid profiles between long-lived cohort and average population in Bama area and this may be one of the genetic bases of its longevity.
Highlights
The peroxisome proliferator-activated receptors (PPARs) belong to a superfamily of nuclear receptors
PPARα and γ are primarily produced in the liver and adipocytes respectively and regulate fatty acid oxidation and adipogenesis whereas PPARδ is ubiquitously expressed, with higher levels found in adipose tissue and skeletal muscle which might involve in the regulation of the β-oxidation of fatty acid [1,2,3,4]
A number of efforts have been directed to the putative link between PPARs and age-related phenotypes such as metabolic syndrome, coronary heart disease (CHD) and Alzheimer’s disease (AD) [5,6], some of which have been well established both in animal and human models
Summary
The peroxisome proliferator-activated receptors (PPARs) belong to a superfamily of nuclear receptors. PPARα and γ are primarily produced in the liver and adipocytes respectively and regulate fatty acid oxidation and adipogenesis whereas PPARδ is ubiquitously expressed, with higher levels found in adipose tissue and skeletal muscle which might involve in the regulation of the β-oxidation of fatty acid [1,2,3,4]. In this context, disturbance in levels or activity of PPARs may elicit metabolic traits. We aimed to evaluate the possible correlation between PPARD +294T/C and serum lipid levels in a long-lived population in Bama, a region known for longevity situated in Guangxi, China
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