PP5 PYLORIC PNEUMATIC DILATION FOR THE TREATMENT OF ANTRAL PEPTIC OBSTRUCTION IN A CHILD

Abstract

tory, with a well-known experience in this field (UV), has carried out antibody tests. Methods: Thirty-three consecutive subjects (without IgA deficiency) including 16 patients with suspected CD (24.6±6.1 month age; 11 females) and 17 controls (20.8±5.5 month age; 5 females) were tested for IgA antiendomysial antibodies (EmA) by indirect immunofluorescence (IFL) on human umbilical cord substrates (home-made method) and for IgA tissue transglutaminase (tTG), IgG DGP and IgG and IgA antigliadin antibodies (AGA) by commercial ELISA kits from Eurospital (Trieste, Italy). Of the 16 patients with suspected CD, 12 had classical gastro-intestinal (GI) symptoms and the remaining 4 showed extra-intestinal signs. The control group included 7 subjects with GI diseases (eosinophilic esophagitis, functional constipation, acute diarrhea) and 10 with non-GI diseases (respiratory, neurological, neonatal infections, congenital malformations). Suspected CD and 4 out of 7 controls with GI symptoms underwent EGDS to obtain 4 duodenal specimens, evaluated by Marsh-Oberhuber classification [1]. Results: All the 16 suspected CD patients were positive for DGP, tTG and EmA. Duodenal biopsy confirmed CD diagnosis showing a villous atrophy (lesion type 3a-b-c). tTG and EmA were consistently negative in all the 17 controls studied, whereas DGP positivity was observed in five cases (two biopsied with a normal mucosa). Both IgG and IgA AGA identified a few number of CD patients.