Abstract
Rationale: Cystic Fibrosis (CF) is a common autosomal recessive disease. The intake and utilization of energy and nutrients are essential for patients with CF to grow properly, to maintain gastrointestinal and lung functions, and also for the genetic potential. The aim of this study was to determine the impact of some variables on growth of patients with CF. Methods: A retrospective cross-sectional study was conducted in a Referral Center for CF (Hospital de Clinicas, Campinas, Brazil). Anthropometric measurements were collected at the following times: at birth, first consultation, time of diagnosis, and annually in the anniversary month of the patient. Other collected variables included, spirometry, fecal fat balance and the presence of pathogens in sputum. It was also investigated exclusive breastfeeding, early gastrointestinal and respiratory manifestations, number of hospitalizations, meconium ileus, pancreatic disease or insufficiency, liver disease, birth weight and parental height. Results: From 52 evaluated individuals under 10 yearsold, four had low height for their age, and four were underweight. The following variables were significantly associated with height to age: number of hospitalizations, time from first consultation to diagnosis, and time between birth and early diagnosis of respiratory disease. Also, there were significantly association with the index BMI/age, spirometry, gestational age, birth weight, and early respiratory symptoms. This study showed that the majority of our patients are eutrophic, but a significant number of patients are in the range of surveillance of nutritional status. Conclusion: For these variables, significant associations were observed between markers of clinical severity of disease and growth. Clinical severity of disease and growth were associated with all markers evaluated. Nutritional follow-up would be helpful to promote the general health and growth.
Published Version
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