PP153—Evaluation of the Relationships Between ABCB1 C3435T and G2677T/A Polymorphisms and Clinical Response to Venlafaxine in Patients with Major Depressive Disorder

Abstract

e66 Volume 35 Number 8S allele A in the study group was 8%, in the control group – 4% (р = 0.1; chi-square). The following genotypes distribution was observed in the study group: АА – 0.02; AG – 0.13; GG – 0.85. In the control group the following genotype distribution was observed: АА – 0.01; AG – 0.05; GG – 0.94. Distributions corresponded to Hardy-Weinberg equilibrium. Conclusion: In our prospective study, we observed tendency to genetic predisposition to higher activity of CYP3A5 in women with stillbirth compared with matched women with normal pregnancy. The results, however, did not reach statistical significance, which may demonstrate either lack of real association or insufficient number of subjects recruited. The observation needs to be proved or disproved in a larger population. Disclosure of Interest: None declared.