Abstract
index [BMI]) and clinical (cardiac and liver involvement, kidney function, C-reactive protein [CRP]) parameters with serum prealbumin levels in 187 newly diagnosed and untreated outpatients affected by immunoglobulin lightchain amyloidosis. Results: Serum prealbumin levels were associated with CRP and short-term energy intake (p < 0.001 for both). A significant association was also detected with age (p = 0.023), serum creatinine (p = 0.017), liver involvement (p = 0.002) and the presence of peripheral edema (p = 0.032). In a pre-specified subgroup analysis (N = 140) on patients with normal CRP (<0.5mg/dL), all the other associations were confirmed. A significant relationship was also observed with gender (p = 0.022) and BMI (p = 0.041). Conclusion: Serum prealbumin is associated with shortterm energy intake independently of the presence of multiple organ involvement and inflammation. Its serum levels should be always interpreted in light of its influencing factors, among which inflammation, liver and kidney function appear predominant.
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