Effect of aerosol salmeterol combined with non-invasive Bi-level positive airway pressure ventilation on the improvement of arterial blood gas indexex and the changes of serum levels of soluble intercellular adhesion molecule-1 and prealbumin in patients with acute exacerbation of chronic obstructive pulmonary disease

Abstract

Objective To explore the effect of aerosol salmeterol combined with non-invasive bi-level positive airway pressure ventilation on the improvement of arterial blood gas index and the changes of serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and prealbumin (PA) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods 86 patients with AECOPD treated at our hospital from January, 2015 to June, 2017 were divided into a control group and an experimental group according to different treatment protocols, 43 cases for each group. The control group were treated by non-invasive bi-level positive airway pressure ventilation and the experimental group by non-invasive bi-level positive airway pressure ventilation and aerosol salmeterol. The curative effects of two groups were observed. The arterial blood gas indexes [arterial oxygen pressure (PaO2), pH value and arterial carbon dioxide partial pressure (PaCO2)] and serum levels of sICAM-1 and PA before and after the treatment were compared between the two groups. Results Compared with the control group, the treatment effect was more significant in the experimental group; and the total effective rate of the experimental group was 90.70% (39/43), which was higher than that of the control group [74.42% (32/43)], with a statistical difference (P<0.05) . Compared with the control group, the pH, PaO2 and serum level of PA in the experimental group were higher and the levels of PaCO2 and serum sICAM-1 were lower than those in the control group, with statistical differences (P<0.05) . Conclusion Aerosol salmeterol combined with non-invasive bi-level positive airway pressure ventilation in the treatment of AECOPD can effectively improve the blood gas analysis indexes, reduce the serum level of sICAM-1 and increase the serum level of PA. And the effect is remarkable. Key words: Acute exacerbation of chronic obstructive pulmonary disease; Aerosol salmeterol; Non-invasive bi-level positive airway pressure ventilation; Arterial blood gas indexes; Serum factors