PP088. The role of microRNA in pathogenesis of preeclampsia-miRNA network analysis.

Abstract

Preeclampsia (PE) is a leading cause of maternal and fetal mortality and morbidity, affecting least 5-8% of all pregnancies worldwide. Several theories (e.g., immunological, placental ischemia, and genetic) have been described to explain pathogenesis of PE. The analysis of different contributing factors (proteins, mRNA, miRNA) are in the higlight of preeclampsia research, leading to an increasing pool of data. Recently, microRNA-s seems to provide feasible biochemical mechanism playing key role in protein translation regulation. The aim of our strudy was to collect datas from literature regarding to different subset of miRNA-s connected to pathways playing role in pathogenesis of preeclampsia. miRNA expression datas were analysied by biostatistical methods, connections in miRNA gene network and graphical representation of connections and crosspoints of supposed pathways were performed. In more than a hundered miRNA-s analysed in different studies most of the reserches concentrate on angiogenesis, trophoblast cell invasion, vascular developement, oxiadtive stress and blood presure regulation. This condition resulting as major crosspoints miRNA-s involved in this pathways: miR-29b, miR-155, miR-195, miR-16, miR-20a, miR-20b. Complex network analysis and graphical presentation in dynamic manner of miRNA pathways and possible consecquences of aletartion in miRNA expression could help in setting of major directions in PE research.