PP.06.26

Abstract

Objective: Cardio-ankle vascular index (CAVI) is a new marker of arterial stiffness and it is independent of the blood pressure (BP) versus traditional marker of arterial stiffness pulse wave velocity (PWV). The values of CAVI in japanese population have been shown in some investigations. The aim of this study is to study the age dependent cut-off values of CAVI in adult urban population of Russian Siberian region. Design and method: Arterial stiffness in 1348 adult, 24–64 (47,4 ± 11,6) years old, men (40,4%) and women (59,6%) in Tomsk were studied by using volumetric sphygmography VaSera VS-1500 (Fukuda Denshi, Japan) in the framework of the epidemiological study ESSAY- RF. The values of CAVI and aorta- ankle pulse wave velocity (a-a PWV) were considered in group of practically healthy 224 persons without CVD and risk factors (arterial hypertension, diabetes mellitus, smoking) and without lipid-lowering treatment. Results: CAVI and a-a PWV values in different age groups of practically healthy persons (n = 224) are presented in Table 1. We did not find significant difference between mens and womens values, but the depending CAVI on the age was CAVI = 4,60 + 0,053*(AGE). In whole group (n = 1348) icreased a-a PWV (more than 90 pc) was found in 37,8% and increased CAVI in 16,6%. In 14,6% we found the increase of both parameters and in 23,2 % only a-a PWV increasing as a BP reaction.Conclusions: The study of arterial stiffness by volumetric sphygmography VaSera VS-1500 (Fukuda Denshi, Japan) in epidemiological project in Russia has been shown as an effective method. Age depending cut-off values of CAVI were considered in adult urban population of Russian Siberian region.