Abstract
Disentangling Arterial Stiffness and Blood Pressure
Highlights
Vascular ageing refers to cellular and molecular mechanisms that eventually lead to vascular dysfunction, which may manifest in a variety of diseases [1]
(early) vascular ageing is commonly assessed by measuring arterial stiffness, often by means of the carotid-femoral pulse wave velocity (PWV) [2]
PWV can change 1) due to acute changes in blood pressure, as well as 2) due to long term remodelling (Figure 1A). Why is this important? Consider two imaginary crosssectional studies on vascular ageing, in which PWV and blood pressure are measured in a range of normotensive to hypertensive subjects
Summary
Vascular ageing refers to cellular and molecular mechanisms that eventually lead to vascular dysfunction, which may manifest in a variety of diseases [1]. Besides the acute relationship between blood pressure and PWV, prolonged increased blood pressure (hypertension) may cause the arterial wall to remodel through deposition of additional wall material (increasing h) [12] and potentially by increasing material stiffness e.g., due to collagen cross-linking (increasing E) [13]. PWV can change 1) due to acute changes in blood pressure, as well as 2) due to long term remodelling (Figure 1A).
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