PP.04.18

Abstract

Objective: To study ethnic characteristics of cardiac remodeling and distribution of various types of remodeling in arterial hypertension (AH). Design and method: Participants were 66 patients (21 men and 45 women) with hypertension II degree, aged 30–65 years. Two ethnic groups were presented: Russian - 31, Kazakh - 35. The average age was 58,1 (CI 54,9; 61,3) years. For presentation, the following parameters by echocardiography were determined: end-diastolic dimension (CRA) of the left ventricle (LV), interventricular septum thickness (IVST) and posterior wall of the left ventricle (TPWLV), left ventricular mass (LVM), the index of left ventricular mass (LVMI). Depending on the values of the index of relative wall thickness (RWT) index and left ventricular mass (LVMI) patients were divided into 4 groups: 1 - patients with normal LV geometry (RWT <0.45); 2 - patients with concentric left ventricular restructuring (RWT > 0,45); 3 - patients with concentric LV hypertrophy (OTS > 0,45 and increased LVMI); 4 - patients with eccentric LV hypertrophy (RWT < 0.45 and increased LVMI). Results: All types of cardiac remodeling were identified among hypertensive patients. Frequently diagnosed type is concentric LVH (42%), less often - the type of eccentric LVH (20%) and significantly less - concentric LV restructuring (8%), while 30% patients were identified with normal LV geometry. Hypertensive patients among Russian population most frequently have concentric type of LVH (38%, p = 0.75), less often - the type of eccentric LVH (31%, p = 0.098) and left ventricular concentric restructuring (8%, p = 0.78). Normal LV geometry was found in 21% of cases (p = 0.23). Hypertensive patients among Kazakh population concentric LVH was significantly prevailed in 42% of cases, normal LV geometry (in 35% of patients). Concentric restructuring was found in 10% of cases and eccentric LVH - 13% of male. Conclusions: Various types of remodeling and ethnic differences were identified. Concentric LVH was determined as a leading option of cardiac remodeling among Russian and Kazakh patients with hypertension, concentric left ventricular restructuring – less often. Significant percentage of patients with normal LV geometry was diagnosed in both study groups.