PP.23.18] ASSOCIATED FACTORS OF NOT ACHIEVING BLOOD PRESSURE GOALS IN TUNISIAN RESISTANT HYPERTENSION POPULATION

Abstract

Objective: Achieving blood pressure (BP) goals in resistant hypertension (RH) is important to prevent clinical complications such as stroke, aortic dissection, myocardial infarction, congestive heart failure, and renal failure. Scanty information is available on resistant hypertension in our country. This study allows us to assess the main risk factors of not achieving BP goals in a Tunisian RH population. Design and method: The study was carried out in 109 adults with RH living in the region of the southeast of Tunisia. According to BP goals achievement after 6 months, patients were divided into two groups: with (n = 68) and without BP goals achieving (n = 41). We aimed to determine the factors of non achieving BP goals. Results: Mean age of the patients was 70.3 ± 10.7 years and 62.4% were female. More than half of the subjects (53.2%) had diabetes mellitus, obese (33%), and (35.8%) with renal function impairment. Clinical BP values amounted to 146.4 ± 27.3/81.7 ± 13.6 mmHg despite the daily use of 3.7 ± 0.7 drugs and a medication adherence rate of 87.3%. BP goals were reached in 62.4% of the patients. In multivariate logistic regression analysis, not achieving BP goals in RH patients is more likely to be associated with cigarette smoking odds ratio (OR) 3.9, 95% confidence interval CI [0.94–16.09], obesity (OR) 2.65, 95% CI [1.04–6.78] and medication no-adherence (OR) 15.05, 95% CI [3.01–75.07]. Conclusions: In our RH patients, to achieve BP goals we should promote compliance to hypertension medications and reducing both cigarette smoking and obesity.