PP.23.12] OXIDATIVE STRESS IN PREECLAMPSIA

Abstract

Objective: The identification of women at high and low risk for Preeclampsia through the clinic, is the best tool so far to determine the use of available resources in the management of these patients. However, these factors predict only 30% of women who develop Preeclampsia and biomarkers in human blood have a modest predictive potential. The heterogeneity of the pathogenesis of Preeclampsia makes it difficult to establish a single biomarker as a predictor of the disease, the clearest chance in the short term may be the combination of several markers. In this study we compare the plasma level of total antioxidant capacity (TAC) and malondialdehyde levels in patients with preeclampsia versus normal pregnancy and followup the outcomes.Design and method: A cohort comparative study which included 56 patients divided in two groups; 28 patients with preeclampsia, of and as a control group 28 normotensive women with a pregnancy of more than 28 weeks. Plasmatic antioxidant capacity and malondialdehyde were determined by ELISA, a clinical followup was made to determine outcomes. Results: Total antioxidant capacity levels were 2679 ± 2014 mEq/l in normal pregnancy, but fell in patients with mild and severe preeclampsia. However, the greatest impact was in women with severe preeclampsia (p < 0.05), but no significant differences were noticed in malondialdehyde levels between the groups. Conclusions: Women with preeclampsia present a reduction in total antioxidant capacity. Severe Preeclampsia depleted antioxidant capacity.