Abstract
Investigation of the protective effect of chrysanthemum extract in ischemic strokes patients is among the challenging issues with the traditional hospital system in general and smart technology-based hospitals in particular. In this study, we have evaluated the protective effect of chrysanthemum extract on patients with ischemic stroke by detecting the severity of stroke, neuronal indexes, and oxidative stress biomarkers. For this purpose, forty-six patients with ischemic stroke were randomly divided into the control group (n = 30) and chrysanthemum group (n = 30). The control group received standard stroke treatment, and the chrysanthemum group was treated with chrysanthemum extract 400 mg/day (200 mg/day, twice/day) on the basis of standard treatment. The groups were compared the effect of saffron capsules using the National Institute of Health Stoke Scale (NIHSS), serum neuron specific enolase (NSE), S100, brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), Su-peroxide dismutase (SOD), and total antioxidant capacity (TAC ) levels, at the time of first day and fourth day after treatment. On the first day after treatment, there was no significant difference in the NIHSS score, serum NSE, S100, BDNF, MDA, SOD, and TAC levels between the chrysanthemum group and the control group (P > 0.05). On the fourth day after treatment, the NIHSS, serum NSE, S100, and MDA levels were significantly reduced in the chrysanthemum group compared to the control group, while the BDNF, SOD, and TAC levels were higher (P < 0.05). In addition, compared to the levels on the first day, the NIHSS, serum NSE, S100, and MDA levels were significantly reduced, and the BDNF, SOD, and TAC levels were increased in the chrysanthemum group on the fourth day (P < 0.05). Chrysanthemum extract has the effects of scavenging oxygen free radicals and antioxidation and has a neuroprotective effect on ischemic stroke patients.
Highlights
Stroke, commonly known as cerebrovascular accident, is a series of cerebrovascular diseases which is caused by cerebrovascular rupture or cerebrovascular blockage [1, 2]. e traditional definition of stroke is based on clinical manifestations, and the clinical characteristic is the sudden loss of neurological function due to infarction or bleeding in the corresponding brain region [3, 4]
We have evaluated the protective effect of chrysanthemum extract on patients with ischemic stroke by detecting the severity of stroke, neuronal indexes, and oxidative stress biomarkers
Forty-six patients with ischemic stroke were randomly divided into the control group (n 30) and chrysanthemum group (n 30). e control group received standard stroke treatment, and the chrysanthemum group was treated with chrysanthemum extract 400 mg/day (200 mg/day, twice/day) on the basis of standard treatment. e groups compared the effect of saffron capsules using the National Institute of Health Stoke Scale (NIHSS), serum neuron specific enolase (NSE), S100, brain-derived neurotrophic factor (BDNF), malondialdehyde (MDA), Su-peroxide dismutase (SOD), and total antioxidant capacity (TAC) levels, at the time of first day and fourth day after treatment
Summary
Commonly known as cerebrovascular accident, is a series of cerebrovascular diseases which is caused by cerebrovascular rupture or cerebrovascular blockage [1, 2]. e traditional definition of stroke is based on clinical manifestations, and the clinical characteristic is the sudden loss of neurological function due to infarction or bleeding in the corresponding brain region [3, 4]. Commonly known as cerebrovascular accident, is a series of cerebrovascular diseases which is caused by cerebrovascular rupture or cerebrovascular blockage [1, 2]. E clinical symptoms are sudden fainting, numbness of lateral limbs, deviation of mouth angle and aphasia, and hemiplegia or even lifethreatening in severe cases [7,8,9]. In the process of cerebral ischemia, it will stimulate oxidative stress response, a series of inflammatory reactions and release neurotoxins, resulting in serious damage to patients’ neurons [10,11,12]. Erefore, improving oxidative stress and neuroprotection play an important role in the treatment of ischemic stroke. Herbal medicines derived from plant extracts with natural antioxidant and pharmacological activities are being increasingly utilized to treat a wide variety of clinical diseases. Chrysanthemum is a species of perennial plant from the Asteraceae family and one of the most important
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