PP.11.05

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Objective: Plasma renin activity (PRA) is accepted as a marker for increased risk of cardiovascular diseases. We examined whether PRA is a risk factor left ventricular structure abnormal in hypertension patients of Han Chinese.Design and method: This cross-sectional study included a total of 879 consecutive Han patients diagnosed essential hypertension who were hospitalization at Department of Hypertension in People's Hospital of Xinjiang Uygur Autonomous Region in China between 2009 and 2013, subjects aged from 30 years to 60 years. All participants who had not taken antihypertensive drugs at least four weeks, or stopped the drug to effect hormone, such as contraception pills, diuretic dihydropyridines calcium antagonist, beta blockers, angiotensin converting enzyme inhibitors and angiotensin II receptor inhibitor. 24-h ambulatory blood pressure monitoring, echocardiography, plasma renin activity and plasma aldosterone were also performed. LV mass index (LVMI) was calculated according to the method of Devereux and Reichek. LV hypertrophy (LVH) was defined as LVMI>=125 g/m2 in men and >=110 g/m2 in women. According to LVMI and RWT, concentric remodeling (CCR), a normal LVMI and RWT>=0.45; concentric hypertrophy (CCH), RWT<0.45 and LVH; eccentric hypertrophy (ECH) RWT>=0.45 and LVH. According to the plasma renin activity lever, participants were classified three renin categories, as follows: low renin, <0.56ng/ml/h (30% of the sample); medium renin, 0.56 to 4.24ng/ml/h (60% of the sample); or high renin,>4.24ng/ml/h(10% of the sample) Results: As compared with low-renin and medium-renin groups, high-renin group had high mean 24-h mean arterial pressure. High-renin group show a high prevalence of LVMI and concentric hypertrophy, eccentric hypertrophy than low and medium renin groups adjusting for sex, age, BMI, and mean 24 hours MAP. Regression models showed that high-renin group showed significantly increased 3.033 fold risk of left ventricular hypertrophy (p < 0.001), compared to low-renin group, as potential confounders for age, gender, BMI, serum creatinine, high-sensitivity C-reactive protein, triglyceride,duration. Conclusions: These results raise the hypothesis that high plasma renin activity may have a deleterious effort on the development of LV structure in essential hypertension.