PP.10.09

Abstract

Objective: we exam 58 patients older 60 years (30 female, mean age 78 ± 0,4). We subdivided this patients in two groups: younger and older 80 years (n = 18). As a control group was patients younger 40 (third group) and patients in age 40–60 (4-th group). Design and method: For all patients we performed of estimation of lipid and glucose levels, echocardiography, 24-hour monitoring of blood pressure (BPLab device, «Petr Telegin», Russia). We estimated pulse wave velocity (PWV), augmentation index (Aix), index of arterial stiffness (ASI), ambulatory index rigidity (AASI). Statistic analyze we performed by «Biostat». Results: PWV in first group was in mean 9,3 ± 0,6 m/s, in second group 10,4 ± 0,5 m/s, in 3-d group 6,97 ± 0,04, in 4-th 8,2 ± 0,4 m/s; p3–1 < 0,05; p3–2 < 0,05. In first group PWV was more in male (10,75 ± 0,3 m/s; in female 8,71 ± 0,38, p < 0,05. In 2-d group PWV was in male 10,1 ± 0,4 m/s, in female 11,5 ± 0,2. In 31% of male and 65% of female older 80 years PWV was than 10 m/s. In patients in 4-th group we obtained more stronger increase PWV in male (8,7 ± 1,3 m/s in contrast in female 7,1 ± 1,3 m/s, p < 0,05). In patients younger 40 we do not obtained statistic differences between male and female. Progression of Aix in patients according to age was more stronger in female. Before 40 Aix in female was -26 ± 0,3% (in male -53,4 ± 0,7). In female in age 40–60 it was -21,3 ± 1,1% (in male -44,2 ± 0,1%). This tendency is preserved in 60–80 years in female -13,7 ± 1,4%, in male -22 ± 0,03, p < 0,05. In female older 80 it was 6,1 ± 0,8%, in male -5 ± 0,02%. According to age of patients we obtained tendency to impair of ASI, AASI. In patients younger 80 alteration of arteries were more stronger in male, after 80- in female. Conclusions: progression of increasing artery stiffness in patients older 60 inhomogeneous. In age 60–80 more strong progression was obtained in male: increasing of PWV, ASI, AASI. In female in this age Aix impair progression was more stronger. In patients older 80 years the most impaired of arterial stiffness was obtained in female. In this process was involved as direct as reflect pulse wave.