Abstract
<h3>Background and objectives</h3> The PREMATurity as pre-dictor of Children’s cardiovascular and renal Health (PRE-MATCH) is a case-control study in former ELBW children (2000–2005) and controls (term) at the median age of 12 years to compare the phenotype, including body compo-sition, renal function and cardiovascular assessment. <h3>Methods</h3> Growth (height, weight, head circumference, Z-scores), body composition (Bodystat), renal function (renal length, cystatin C converted to eGFR), cardiovascu-lar assessment and retinal vascular aspects were assessed in former ELBW children and controls. <h3>Results</h3> Former ELBW children still have difficulties to reach their target height. ELBW adolescents show lower neurocognitive performance, grip strength and high-er fat body mass. Catch–up growth for weight in ELBW children in the first two years of life was associated with lower fat body mass. Renal length and glomerular filtra-tion rate (cystatin C) were 0.28 cm (95% CI 0.09–0.47) and 11.5 mL/min/1.73 m2 (6.4–16.6) lower in cases. The odds of having systolic (pre)hypertension in former ELBW cases was 6.43 (2.52–16.4) and 10.9 (2.46–48.4) with a low renin mechanism. Microvascular retinal arteriolar narrowing is observed in former ELBW young adolescents. <h3>Conclusions</h3> The phenotype (growth, body composi-tion, renal function, retinal microvascularisation) of former ELBWs differs significantly from controls in early adoles-cence. All these findings reflect mechanisms related to a higher risk factor for adverse health outcomes in adult-hood.
Published Version
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