Abstract
Salmeterol + fluticasone combination in a single inhaler was introduced to the asthma treatment 20 years ago. Since then, it possess the prominent place in asthma and COPD treatment guidelines. Due to safety and efficacy it belongs to first choice asthma treatment from step 3 through 5 in GINA 2019 guidelines. It reduces airway hyperreactivity and increases the number of asthma free-days and the number of days without rescue medication.
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