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Abstract
Diabetes is a widespread and serious disease and noninvasive measurement has been in high demand. To address this problem, a power spectral density-based method was offered for determining glucose sensitive sub-bands in the nearinfrared (NIR) spectrum. The experiments were conducted using phantoms of different optical properties in-vitro conditions. The optical bands 1200–1300[Formula: see text]nm and 2100–2200[Formula: see text]nm were found feasible for measuring blood glucose. After that, a photoplethysmography (PPG)-based low cost and portable optical system was designed. It has six different NIR wavelength LEDs for illumination and an InGaAs photodiode for detection. Optical density values were calculated through the system and used as independent variables for multiple linear regression analysis. The results of blood glucose levels for 24 known healthy subjects showed that the optical system prediction was nearly 80% in the A zone and 20% in the B zone according to the Clarke Error Grid analysis. It was shown that a promising easy-use, continuous, and compact optical system had been designed.
Highlights
Noninvasive blood glucose measurements have been studied for four decades
A power spectral density method was proposed for determining representative glucose bands in the NIR spectrum
Di®erent glucose concentrations were added into the prepared tissue phantoms which had di®erent scattering properties
Summary
Noninvasive blood glucose measurements have been studied for four decades It is still a popular and worthwhile research topic due to the fact that the number of diabetic people has increased dramatically in recent years. The latest global report on diabetes by the World Health Organization points out that one out of eleven people is diabetic This is an Open Access article published by World Scientic Publishing Company. Worldwide.[1] It is suggested by health institutions that diabetic patients should check their blood glucose levels 3 or 4 times daily to control their glycosylated hemoglobin levels. This continuous monitoring is crucial for a quality life standard. There is no NIH approved noninvasive blood glucose measurement device or method.[2,3] Some of the noninvasive blood glucose measurement study summaries are described in what follows
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