Abstract
Three strains of mice (CAF1, C3H and C57 Black) were treated with various dose combinations of urethan and epinephrine. Duration of anesthesia, lethal toxicity and survival time were observed, with the following findings: 1. Epinephrine lethal toxicity was greatest in C57 Black mice and lowest in the CAF1 strain. 2. In all strains, urethan anesthetic time was greatly prolonged; this effect increased with dose of epinephrine. 3. Urethan reduced lethal toxicity of epinephrine; with increase of dose of epinephrine, reduction of toxicity was less. 4. Urethan anesthetic time was also potentiated by nor-epinephrine; its lethal toxicity was somewhat reduced by urethan. 5. Anesthetic time of phenobarbital sodium and of pentobarbital sodium was slightly potentiated by epinephrine. These agents did not reduce the lethal toxicity of epinephrine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
