Abstract
1. 1. A kinetic study was made of the effects of hyperthermia and cell specific antibody on non-synchronized lag phase cultures and synchronized exponentially growing cultures of a malignant cell line. The effects on the degree of cell synchrony were also investigated. 2. 2. Hyperthermic treatment of synchronized SDB monolayer cell populations with maximum replication rate sensitized the cells to subsequent destruction by cell specific antibody. 3. 3. Hyperthermic treatment of SDB monolayer cultures with low replication rate and varying degrees of metabolic activity produced no such sensitization. 4. 4. Hyperthermia was disruptive to a synchrony procedure involving a blockade of DNA synthesis by excess thymidine.
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