Abstract
Research in Medical & Engineering Sciences Potentiation of the Antidepressant Effects of Fluoxetine by Administration of Aspirin in a Mouse Model Yousef A Taher1, Fatma M Rabie1, Souad Y Fruja1, Awatef M Samud2, Fathy E El-Taher3, and Fathi M Sherif1* 1Department of Pharmacology and Clinical Pharmacy, University of Tripoli, Libya 2Department of Anaesthesia and Intensive Care, University of Tripoli, Libya 3Department of Orthodontic, Faculty of Dentistry, University of Tripoli, Libya *Corresponding author: Fathi Mohamed Sherif, Department of Pharmacology and Clinical Pharmacy, University of Tripoli, Libya Submission: November 14, 2017; Published: January 12, 2018 DOI: 10.31031/RMES.2018.03.000556 ISSN: 2576-8816Volume3 Issue2
Highlights
Previous studies have demonstrated that major depressive disorder (MDD) is rank fourth position among mood disorders and worldwide is considered as the most prevalent psychiatric condition [1]
The remarkable association between attempted suicide and delay in the onset of remission of depressive episodes did lead the researchers exploring for a new line of treatments for patients who are suffering from MDD
In the two behavioral models, mouse forced-swim test and tailsuspension test, it was clearly observed that combination of aspirin with fluoxetine produced an antidepressant-like effect to a greater extent than fluoxetine alone, as demonstrated by a mean decrease in duration of immobility time from baseline values
Summary
Previous studies have demonstrated that major depressive disorder (MDD) is rank fourth position among mood disorders and worldwide is considered as the most prevalent psychiatric condition [1]. Amelioration in the clinical efficacy of patients with major depression [5], and the improvement in the antidepressant efficacy in experimental animals [6] after the concurrent administration of NSAIDs with SSRIs were proved to be mediated by immunological events. It has been shown that administrations of anti-inflammatory drugs improve the patient’s psychiatric condition. These facts suggest that NSAIDs may be used as an adjunctive therapy in the management of depression. We investigated whether a combination of suboptimal dose of the selective serotonin reuptake inhibitor, fluoxetine, with aspirin improves the anti depressive effects of fluoxetine
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