Potential Thyrotropic and Antihypercholesteronemic Activity Exhibited by Ethanolic Extract of Crataeva nurvala Bark

doi:10.7324/japs.2017.71110

Abstract

Highlights

Levothyroxine (LT4) is the standard replacement therapy in hypothyroidism, clinically that offers a similar life quality, whereas the psychological well being is compromised (Garber et al, 2012; Petersen et al, 1990; Jonklaas et al, 2008; Saravanan et al, 2002)
This study aims to evaluate the effect of the ethanolic extract of Crataeva nurvala (CNet) bark, on free thyroxine (FT4), thyroid stimulating hormone (TSH) and serum cholesterol (CHO) in Swiss albino female adult mice over conventional therapy
Crataeva nurvala was found effective at higher dose, that suggest its beneficial role in treating hypothyroidism and associated hypercholesteronemia

Summary

Introduction

Levothyroxine (LT4) is the standard replacement therapy in hypothyroidism, clinically that offers a similar life quality, whereas the psychological well being is compromised (Garber et al, 2012; Petersen et al, 1990; Jonklaas et al, 2008; Saravanan et al, 2002). F and Varuna (Khare, 2007; Daniel, 2006). In Ayurveda, thyroid disorders are discussed under the term “Galaganda” (enlarged thyroid gland). Ayurveda supports use of Varuna leaves, stem bark and root bark in regulating equilibrium among three doshas (bodily humours) Vata (air), Pitta (earth) and Kapha (mucous or water), whose imbalance leads to hormonal imbalance (Ojus), most commonly thyroid disorders (Kaur et al, 2016). It was hypothesized that this plant can have beneficial effects in hypothyroidism

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