Abstract
Water and ethanol extracts of Gambia albidumleaf and bark were studied for their wound healing potential. The biochemical parameters studied were: serum total protein, monoamine oxidase (MAO) activity, ascorbic acid, protease activity and cysteine. The rats were grouped into control (C) on which about 20mm wounds were made but not treated, while groups A1, A2, B1 and B2 were treated with 500mg/kg body weight of the extracts for 10 days. Olive oil suspensions of the extracts were also applied topically to the wounds throughout the period of the study. The mean percentage reductions of the wound diameters were: control (43.60%); A1 (treated with water extract of bark - 65.30%); A2 (treated with ethanol extract of bark - 76.79%); B1 (treated with water extract of leaves - 53.96%); and B2 (treated with ethanol extract of leaves - 60.84%). The serum levels of the parameters after administering water extract of the leaves were: total protein (0.686±0.000mg/100ml), MAO (1.325±0.023µ/l), ascorbic acid (51.50±0.736mg/100ml), protease (1.880±0.047µg/100ml) and cysteine (22.22±0.686mg/100ml). The mean levels after water extracts of the bark were: total protein (0.754±0.026mg/100ml), MAO (1.103±0.195µ/l), ascorbic acid (50.08±2.383mg/100ml), protease (1.743±0.063µg/100ml), and cysteine (23.37±0.635mg/100ml). The mean levels in the animals given ethanol extract of the leaves were: total protein (0.767±0.012mg/100ml), MAO (1.424±0.031µ/l), ascorbic acid (54.50±0.408mg/100ml), protease (1.700±0.034µg/100ml) and cysteine (24.66±0.316mg/100ml). The mean values caused by ethanol extract of the bark were: total protein (0.824±0.018mg/100ml), MAO (1.374±0.045µ/l), ascorbic acid (56.75±1.541mg/100ml), protease (1.552±0.051µg/100ml) and cysteine (25.07±0.469mg/100ml). The results of this study showed that both water and ethanol extracts were effective in promotion wound healing. However, the ethanol extracts of both the leaves and bark were more effective than those of water. Keywords:Gambia albidum,total protein,monoamine oxidase,ascorcbic acid,protease,
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