Abstract
Potential Therapeutic Effects and Bioavailability of Wogonin, the Flavone of Baikal Skullcap
Highlights
Cancer or malignant neoplasm is a group of deadly diseases that results from genetic or epigenetic al-Citation: Gharari Z, Bagheri K, Khodaeiaminjan M, Sharafi A (2019) Potential Therapeutic Effects and Bioavailability of Wogonin, the Flavone of Baikal Skullcap
Modern science proved that wogonin is one of the major bioactive agents responsible for the physiological activity of Baikal skullcap (Scutellaria baicalensis Georgi.), which has been regarded as a potent anticancer agent
The results showed that wogonin and the flavones apigenin and chrysin breaks Tumor necrosis factor related apoptosis inducing ligand (TRAIL) resistance in human T-cell leukemia virus type 1 (HTLV1) associated adult T-cell leukemia/lymphoma (ATL) by inhibition of Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) transcription and by upregulation
Summary
Cancer or malignant neoplasm is a group of deadly diseases that results from genetic or epigenetic al-. The anti-inflammatory properties of wogonin, such as inhibition of nitric oxide (NO) [27], 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 expression [10,28] and prostaglandin E2 production [29,30,31,32] have been reported previously. The inflammatory effect of wogonin on the gene expression of cyclooxygenase-2 in human lung epithelial cancer cells reported by Chen, et al [40].
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