Abstract
Objectives: To review exosomes in aging and age-associated diseases. Design: A review study. Participants: Aged animals. Interventions: Exosome treatment. Outcome measures: The occurrence of age-associated diseases, aging skin, cognition, and cardiac dysfunction. Results: Exosomes are secreted by various cell types and comprise proteins, lipids, functional messenger RNAs, cytokines, growth factors, different noncoding RNA, micro-RNAs, and other bioactive substances. These nanoparticles are implicated in several physiological processes, including intercellular communication, cell migration, angiogenesis, and anti-tumor immunity, and have gained major interest in regenerative medicine. Furthermore, several studies have demonstrated the potential roles of exosomes in age-associated diseases such as aging skin, cognition, Alzheimer’s disease (AD), Parkinson’s disease (PD), and osteoarthritis (OA). Conclusions: We summarized various mechanisms of exosomes in the treatment of age-related diseases, including OA, PD, AD, and aged skin. These vesicles can be of efficient medicinal value for aged-associated disease therapy in preclinical trials. Further clinical trials are needed, but the majority of the literature suggests research directions that may provide new treatment approaches and strategies for clinical application.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
